Key result
Orthostatic hypotension is associated with cardiovascular disease, and impaired orthostatic hemodynamic response should be considered as a new risk factor for atrial fibrillation.
Why the study?
The clinical significance of orthostatic hypotension is underestimated despite its association with mortality and cardiovascular disease, prompting a review of its relationship with atrial fibrillation.
Is there a relationship between orthostatic hypotension and atrial fibrillation?
Orthostatic hypotension may represent a novel risk factor for atrial fibrillation, highlighting a potential link between autonomic dysfunction and arrhythmogenesis.
May support considering orthostatic response in AF risk evaluation but should not yet change practice; leaves open need for prospective validation.
Orthostatic hypotension (OH), a possible marker of autonomic dysfunction, reflects the inability of reflex cardiovascular mechanisms to compensate for the fall in venous return in the upright position. This is a manifestation of structural and functional abnormalities of the cardiovascular system. Significance of the orthostatic hypotension is underestimated, while it is associated with all-cause mortality and cardiovascular disease. The article reviews the relationship between atrial fibrillation (AF) and OH. The pathogenetic mechanisms of OH are considered, including various subgroups, e. g. elderly patients. The article also discusses the relationship between OH, AF and cerebrovascular complications. Available evidence suggests that impaired orthostatic hemodynamic response should be considered as a new risk factor for AF. Further research is needed for better understanding of the association between AF and OH, as well as their management.
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Антропова et al. (2021) conducted a review in Orthostatic hypotension and atrial fibrillation. Orthostatic hypotension was evaluated. Orthostatic hypotension is associated with cardiovascular disease, and impaired orthostatic hemodynamic response should be considered as a new risk factor for atrial fibrillation.
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