Key result
Orthostatic hypertension was associated with a 27% increased risk of long-term all-cause mortality at 17 years compared to a normal orthostatic response in older adults with isolated systolic hypertension (HR 1.27, 95% CI 1.06-1.53, p=0.0096).
Why the study?
The study examined the association between orthostatic hypertension and all-cause mortality in older persons with isolated systolic hypertension.
Does orthostatic hypertension increase the risk of all-cause mortality in older adults with isolated systolic hypertension?
Population
4736 men and women aged 60 years and above with isolated systolic hypertension in SHEP
Comparison
Orthostatic hypertension vs normal orthostatic response
Design
Post-hoc analysis of a multicenter randomized double-blind placebo-controlled trial
Follow-up
4.5 and 17 years
Authors
Loading...
May not yet change practice in isolated systolic hypertension; leaves open whether orthostatic hypertension is a modifiable target.
Cohort (n=4,714)
Double-blind
Yes
Does orthostatic hypertension increase the risk of all-cause mortality in older adults with isolated systolic hypertension?
Hazard Ratio: 1.27 (95% CI 1.06–1.53)
p-value: p=0.0096
Orthostatic hypertension is an easily detectable clinical sign that independently predicts long-term all-cause mortality in older adults with isolated systolic hypertension.
Kostis et al. (2019) conducted a cohort in Isolated systolic hypertension (n=4,714). Orthostatic hypertension vs. Normal orthostatic response was evaluated on All-cause mortality at 17 years (fully adjusted) (HR 1.27, 95% CI 1.06-1.53, p=0.0096). Orthostatic hypertension was associated with a 27% increased risk of long-term all-cause mortality at 17 years compared to a normal orthostatic response in older adults with isolated systolic hypertension (HR 1.27, 95% CI 1.06-1.53, p=0.0096).
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