Key result
Systolic orthostatic hypotension after 2 minutes of standing was a significant independent predictor of first cardiovascular events in elderly patients (adjusted HR 2.38; P<0.01).
Why the study?
Does orthostatic hypotension predict incident cardiovascular events more robustly than nighttime reverse dipping in an elderly primary care population?
Population
374 elderly patients, mean age 70.2+/-8.5 years, registered in 1 primary care practice and without major…
Comparison
Orthostatic hypotension vs Nighttime reverse dipping on ambulatory blood…
Design
Cohort
Follow-up
3406 patient-years
Authors
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May support orthostatic hypotension assessment in elderly primary care; leaves open superiority over nighttime reverse dipping pending validation.
Cohort (n=374)
No
Does orthostatic hypotension predict incident cardiovascular events more robustly than nighttime reverse dipping in an elderly primary care population?
Hazard Ratio: 2.38
p-value: p=<0.01
Orthostatic hypotension, particularly 2 minutes after standing, is a stronger independent predictor of cardiovascular events than nighttime reverse dipping in elderly patients.
Fagard et al. (2010) conducted a cohort in Elderly without baseline cardiovascular events (n=374). Orthostatic hypotension vs. Absence of orthostatic hypotension was evaluated on First cardiovascular events (death, myocardial infarction, or stroke) (HR 2.38, p=<0.01). Systolic orthostatic hypotension after 2 minutes of standing was a significant independent predictor of first cardiovascular events in elderly patients (adjusted HR 2.38; P<0.01).
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