May 1, 2009Journal of Hypertension
Orthostatic hypotension in genetically related hypertensive and normotensive individuals
Key result
Hypertension was associated with a higher prevalence of orthostatic hypotension compared to normotensive first-degree relatives (13.4% vs 5.5%).
Why the study?
What are the prevalence and determinants of orthostatic hypotension in middle-aged hypertensive patients compared to their normotensive relatives?
Population
922 middle-aged individuals, comprising 469 hypertensive patients and 453 of their normotensive first-degree…
Design
Cohort
Follow-up
6.6 years
Authors
Discussion
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Implication
May warrant orthostatic hypotension screening in hypertensives; leaves open treatment effects and causality.
Study Design
Type
Cohort (n=922)
Structured PICO
What are the prevalence and determinants of orthostatic hypotension in middle-aged hypertensive patients compared to their normotensive relatives?
P
Population
922 middle-aged hypertensive patients and their normotensive first-degree relatives, followed for 6.6 years.
O
Outcome
Frequency and determinants of orthostatic hypotension
Main Result
Absolute Event Rate: 13.4% vs 5.5%
Orthostatic hypotension is more prevalent in hypertensive patients than normotensive relatives and is associated with female sex, reduced renal function, and higher blood pressure, while antihypertensive treatment (especially ACE inhibitors) appears protective.
Limitations
- The prognostic value of impaired orthostatic response regarding risk of cardiovascular disease and mortality remains uncertain and requires further studies.
Cite This Study
Fedorowski et al. (2009) conducted a cohort in Hypertension (n=922). Hypertension vs. Normotension was evaluated on Orthostatic hypotension. Hypertension was associated with a higher prevalence of orthostatic hypotension compared to normotensive first-degree relatives (13.4% vs 5.5%).