Key result
Left ventricular diastolic dysfunction was significantly more prevalent among normotensive type 2 diabetic patients with microalbuminuria (71.1%) compared to those without microalbuminuria (49.1%).
Why the study?
The study was conducted to find out and compare left ventricular diastolic dysfunction and its pattern among patients with type-2 diabetes mellitus with and without micro-albuminuria.
Does the presence of microalbuminuria associate with an increased prevalence of left ventricular diastolic dysfunction in normotensive patients with type 2 diabetes mellitus?
Cross-Sectional (n=228)
No
Does the presence of microalbuminuria associate with an increased prevalence of left ventricular diastolic dysfunction in normotensive patients with type 2 diabetes mellitus?
Absolute Event Rate: 71.1% vs 49.1%
p-value: p=0.004
Microalbuminuria is associated with a significantly higher prevalence of echocardiographic left ventricular diastolic dysfunction in normotensive patients with type 2 diabetes.
Microalbuminuria was associated with higher LVDD prevalence in normotensive T2DM; hypothesis-generating, prospective studies needed before screening implications.
Objective: To find out and compare left ventricular diastolic dysfunction and its pattern among patients with type-2 diabetes mellitus (T2DM) with and without micro-albuminuria. Methodology: This comparative cross section study was conducted in the outpatient department of Peshawar Institute of Cardiology from August 2021 to January 2022. A total of 228 T2DM normotensive patients, aged 30 to 65 years were enrolled and divided into two groups. Group-A contained 114 T2DM with no-albuminuria and Group-B had 114 T2DM micro-albuminuria patients. Socio-demographic, anthropometric, laboratory characteristics and echocardiographic parameters of all patients were noted. Qualitative variables were analyzed using chi-square test while quantitative variables were analyzed using t-test. P value <0.05 was considered statistically significant. Results: Out of a total of 228 patients, 122 (53.5%) were male. Overall, mean age was noted to be 49.18+8.8 years. In comparison to group-A, duration of diabetes was significantly more among patients of group-B (p<0.001). Renal functions were significantly preserved in Group-A in comparison to Group-B (p=0.003) as shown by eGFR. Left ventricular diastolic dysfunction was found to be 49.1% among patients of Group-A in comparison to 71.1% in Group-B and pattern of left ventricular diastolic dysfunction showed a significant difference between patients of both study groups (0.004). Conclusion: Left ventricular diastolic dysfunction was significantly high among T2DM patients with micro-albuminuria. Significant associations were found in terms altered left ventricular diastolic echocardiographic features among T2DM patients with micro-albuminuria.
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Manzoor et al. (2023) conducted a cross-sectional in Type 2 diabetes mellitus (n=228). Micro-albuminuria vs. Normo-albuminuria was evaluated on Left ventricular diastolic dysfunction (p=0.004). Left ventricular diastolic dysfunction was significantly more prevalent among normotensive type 2 diabetic patients with microalbuminuria (71.1%) compared to those without microalbuminuria (49.1%).
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