Key result
Serum markers of myocardial injury and inflammation did not significantly differ between patients who developed postpericardiotomy syndrome (12.5%) and those who did not.
Why the study?
Are perioperative serum markers of myocardial injury and inflammation associated with the occurrence of postpericardiotomy syndrome in patients undergoing cardiac surgery?
Cohort (n=96)
Are perioperative serum markers of myocardial injury and inflammation associated with the occurrence of postpericardiotomy syndrome in patients undergoing cardiac surgery?
Serum markers of myocardial injury and inflammation do not correlate with the development of postpericardiotomy syndrome after cardiac surgery, although younger age appears to be a clinical risk factor.
Serum markers should not guide postpericardiotomy syndrome prediction; hypothesis-generating for alternative mechanisms in cardiac surgery.
OBJECTIVE: To verify the association of serum markers of myocardial injury, such as troponin I, creatinine kinase, and creatinine kinase isoenzyme MB, and inflammatory markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein, and the erythrocyte sedimentation rate in the perioperative period of cardiac surgery, with the occurrence of possible postpericardiotomy syndrome. METHODS: This was a cohort study with 96 patients undergoing cardiac surgery assessed at the following 4 different time periods: the day before surgery (D0); the 3rd postoperative day (D3); between the 7th and 10th postoperative days (D7-10); and the 30th postoperative day (D30). During each period, we evaluated demographic variables (sex and age), surgical variables (type and duration, extracorporeal circulation), and serum dosages of the markers of myocardial injury and inflammatory response. RESULTS: Of all patients, 12 (12.5%) met the clinical criteria for a diagnosis of postpericardiotomy syndrome, and their mean age was 10.3 years lower than the age of the others (P=0.02). The results of the serum markers for tissue injury and inflammatory response were not significantly different between the 2 assessed groups. No significant difference existed regarding either surgery duration or extracorporeal circulation. CONCLUSION: The patients who met the clinical criteria for postpericardiotomy syndrome were significantly younger than the others were. Serum markers for tissue injury and inflammatory response were not different in the clinically affected group, and did not correlate with the different types and duration of surgery or with extracorporeal circulation.
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Köhler et al. (2003) conducted a cohort in Postpericardiotomy syndrome (n=96). Serum markers of myocardial injury and inflammation vs. Patients without postpericardiotomy syndrome was evaluated on Postpericardiotomy syndrome. Serum markers of myocardial injury and inflammation did not significantly differ between patients who developed postpericardiotomy syndrome (12.5%) and those who did not.
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