Key result
Sodium cromoglycate reduced or abolished reflex changes in arterial blood pressure induced by phenylbiguanide, but had no effect on responses to capsaicin or vagal stimulation in guinea pigs.
Why the study?
Does sodium cromoglycate influence cardiovascular and pulmonary responses to phenylbiguanide, capsaicin, and vagal stimulation in anesthetized guinea pigs?
Does sodium cromoglycate influence cardiovascular and pulmonary responses to phenylbiguanide, capsaicin, and vagal stimulation in anesthetized guinea pigs?
Answers are grounded in this paper and cite their sources.
Sodium cromoglycate may influence both afferent and efferent pathways of responses to drugs, specifically reducing phenylbiguanide-induced reflex blood pressure changes in a guinea pig model.
The effects of sodium cromoglycate (SCG) on cardiovascular and pulmonary responses to phenylbiguanide, capsaicin, and vagal stimulation were studied in anesthetized guinea pigs. Phenylbiguanide had no bronchospastic activity but induced reflex changes in arterial blood pressure which were reduced or abolished by SCG. Capsaicin induced nonreflex bronchospasm, and decreases in arterial blood pressure that were unaffected by SCG. Sodium cromoglycate, given before or after atropine, had no effect on the bronchospasm and cardiovascular responses to unilateral or bilateral stimulation of the vagus nerves. We conclude that SCG may influence both the afferent and efferent pathways of responses to drugs.
No takes yet. Share an insight, caveat, or question.
Biggs et al. (1985) studied this question. Sodium cromoglycate (SCG) was evaluated on Cardiovascular and pulmonary responses to phenylbiguanide, capsaicin, and vagal stimulation. Sodium cromoglycate reduced or abolished reflex changes in arterial blood pressure induced by phenylbiguanide, but had no effect on responses to capsaicin or vagal stimulation in guinea pigs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: