Why the study?
Does sodium cromoglycate stimulate afferent nerves and alter cardiovascular parameters in healthy volunteers?
Does sodium cromoglycate stimulate afferent nerves and alter cardiovascular parameters in healthy volunteers?
Sodium cromoglycate appears to stimulate afferent sensory nerves in humans, producing subjective warmth and systemic cardiovascular responses without local vasodilation.
Answers are grounded in this paper and cite their sources.
Cromoglycate may stimulate afferent nerves with cardiovascular effects in volunteers; hypothesis-generating and leaves open clinical relevance.
Sodium cromoglycate was given by both intravenous injection and local intra-arterial infusion to healthy volunteers. Intravenous injection of a dose of 4 mg in four subjects caused a statistically significant rise in blood pressure and pulse rate associated with a feeling of warmth in the perineum and blush areas of the face and chest. Brachial artery infusion of sodium cromoglycate at doses of 100-1000 microgram/min caused a feeling of warmth in the limb during 26 out of 30 infusions and this sensation was subject to tachyphylaxis. During eight infusions in which there was a sensation of warmth there was no change in local blood flow as measured by strain-gauge plethysmography. In a further six studies involving 12 infusions of sodium cromoglycate the feeling of warmth was not accompanied by a rise in local skin temperature. The results suggest that sodium cromoglycate may stimulate afferent nerves in man.
No takes yet. Share an insight, caveat, or question.
Collier et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: