Why the study?
Do atropine and L-NAME alter cutaneous blood flow during body heating in humans?
Population
6 human subjects undergoing body heating with a water-perfused suit
Comparison
Atropine followed by L-NAME administered via… vs Baseline cutaneous vascular conductance during…
Design
Other
Authors
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Questions reliance on muscarinic NO release for heat-induced cutaneous vasodilation; leaves open non-cholinergic NO sources in human thermoregulation.
Do atropine and L-NAME alter cutaneous blood flow during body heating in humans?
The study demonstrates that neither sweating nor nitric oxide release via muscarinic receptor activation is essential for sustaining cutaneous vasodilation during body heating in humans.
Shastry et al. (2000) studied this question.
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