Key points are not available for this paper at this time.
Introduction Shortly after human skin is injured the area for several centimeters surrounding the site of injury gradually becomes reddened. This flare is a component of the inflammatory response, represents neurogenic vasodilatation,1-3and probably is mediated through the release of one or more Vasodilator substances.4-6The threshold for pain in the flare zone is lowered.7 These phenomena have been the topic of a series of investigations in this laboratory7-11; in this report an attempt is made to define more carefully (a) the nervous pathways implicated and (b) the nature of the mediator substance. Antidromic Vasodilatation after Stimulation of the Distal Portion of Transected Dorsal Roots.—In 1874 Goltz12demonstrated that the sciatic nerve contains fibers that induce vasodilatation when stimulated. Shortly thereafter, Stricker13concluded that in opposition to the Bell-Magendie law, certain vasodilator fibers apparently leave the spinal cord through the dorsal roots, since
Loring F. Chapman (Thu,) studied this question.