January 1, 2008Hypertension ResearchOpen Access

Association between Arterial Stiffness and Cerebral White Matter Lesions in Community-Dwelling Elderly Subjects

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Why the study?

Is increased arterial stiffness (measured by ba-PWV) associated with the presence of cerebral white matter lesions in asymptomatic elderly subjects?

Population

132 elderly asymptomatic subjects, mean age 70.3 years, living in a rural community in Japan. Exclusions…

Design

Cross-sectional, MRI scans were reviewed independently by two authors blinded…

Authors

TOTakahiro OhmineHiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital YMYoshikazu MiwaShowa University HYHiroshi YaoMie University

Discussion

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Implication

ba-PWV may aid PVH risk stratification in asymptomatic elderly; hypothesis-generating for arterial stiffness in cerebral small vessel disease and requires prospective confirmation.

Structured PICO

Is increased arterial stiffness (measured by ba-PWV) associated with the presence of cerebral white matter lesions in asymptomatic elderly subjects?

Population

132 elderly asymptomatic subjects (49 men, 83 women), mean age 70.3 years, living in a rural community in Japan. Exclusions: history of stroke, silent brain infarction on MRI, arrhythmia including atrial fibrillation, or suspected peripheral arterial disease (ABI <0.9).

Intervention

Measurement of brachial-ankle pulse wave velocity (ba-PWV) as a marker of arterial stiffness

Outcome

Presence of cerebral white matter lesions (WMLs) on MRI, specifically periventricular hyperintensities (PVH) and deep white matter lesions (DWML)surrogate

Limitations

Frequent use of antihypertensive agents among hypertensive subjects, which may have diminished the observed effects of systolic blood pressure and pulse pressure.

Cite This Study

Ohmine et al. (2008) studied this question.

synapsesocial.com/papers/6a21f67189ae9bae15e21c19 https://doi.org/10.1291/hypres.31.75

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Implication

ba-PWV may aid PVH risk stratification in asymptomatic elderly; hypothesis-generating for arterial stiffness in cerebral small vessel disease and requires prospective confirmation.

Association between Arterial Stiffness and Cerebral White Matter Lesions in Community-Dwelling Elderly Subjects

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Association between Arterial Stiffness and Cerebral White Matter Lesions in Community-Dwelling Elderly Subjects

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider