Why the study?
Does removal of the provoking stimulus reverse experimentally induced cardiac hypertrophy in rats?
Does removal of the provoking stimulus reverse experimentally induced cardiac hypertrophy in rats?
In rat models of cardiac hypertrophy, removal of the provoking stimulus leads to regression of heart size, protein, and RNA, but newly synthesized DNA largely remains.
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Cardiac hypertrophy regression in rats spares new DNA; leaves open its role in human remodeling.
Enlargement of the heart was produced in rats by four methods: (a) unilateral nephrectomy with DOC pellet implantation and salt loading, (b) experimental hyperthyroidism, (c) experimental aortic coarctation, and (d) nutritional anemia. All enlargements proved to be reversible if the provoking stimulus was removed. In hearts enlarged by anemia up to 80–100%, the extra protein and RNA synthesized during the process of accelerated growth of the heart disappeared as the size of the heart reverted to normal. In this way, the concentration of these two macromolecules remained the same, in spite of the changes in the size of the heart. On the other hand, a large part of the new DNA was not removed during regression.
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Beznák et al. (1969) studied this question.
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