Key result
Higher stroke mortality risk score linked to ~6.5-fold higher odds of severe stroke in hypertriglyceridemic men.
Why the study?
Sex differences in poststroke hypertriglyceridemia and high stroke severity among ischemic stroke patients were not well defined.
What are the sex-specific demographic and clinical determinants of increased stroke severity in acute ischemic stroke patients with hypertriglyceridemia?
Cohort (n=765)
No
What are the sex-specific demographic and clinical determinants of increased stroke severity in acute ischemic stroke patients with hypertriglyceridemia?
Odds Ratio: 6.474 (95% CI 3.262–12.847)
p-value: p=<0.001
Different clinical risk factors, notably blood pressure components, independently predict stroke severity on admission in male versus female patients presenting with acute ischemic stroke and hypertriglyceridemia.
These observational associations should not yet change practice; leaves open whether sex-specific mortality scores warrant prospective validation in hypertriglyceridemic stroke.
Objective: This study aims to determine sex differences in poststroke hypertriglyceridemia (serum triglyceride levels ⩾ 200 mg/dl) and high stroke severity in ischemic stroke patients. Method: Our study analyzed data from 392 males and 373 females with hypertriglyceridemia. Stroke severity on admission was measured using the National Institute of Health Stroke Scale (NIHSS) with a value ⩽7 indicating a more favorable post-stroke prognosis while a score of >7 indicates poorer post-stroke outcomes. Logistic regression models adjusted for demographic and risk factors. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for each clinical risk factor were used to predict the increasing odds of an association of a specific clinical baseline risk factor with the male or female AIS with hypertriglyceridemia. Results: In the adjusted analysis, male patients with hypertriglyceridemia, diastolic blood pressure (OR = 1.100, 95% CI, 1.034-1.171, P = .002), and Ischemic stroke mortality (OR = 6.474, 95% CI, 3.262-12.847, P < .001) were significantly associated with increased stroke severity. In female patients with hypertriglyceridemia, age (OR = 0.920, 95% CI, 0.866-0.978, P = .008) was associated with reduced stroke severity, while ischemic stroke mortality score (OR = 37.477, 95% CI, 9.636-145.756, P < .001) was associated with increased stroke severity. Conclusion Increased ischemic stroke mortality risk score was associated with increased severity in both male and female AIS patients with hypertriglyceridemia. Our findings provide information about sex differences in specific risk factors that can be managed to improve the care of male and female ischemic stroke patients with hypertriglyceridemia.
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Imeh-Nathaniel et al. (2024) conducted a cohort in Acute ischemic stroke with hypertriglyceridemia (n=765). Clinical and demographic risk factors (e.g., ischemic stroke mortality score, blood pressure) vs. Lower levels or absence of the specific risk factors was evaluated on Increased stroke severity (NIHSS > 7) (OR 6.474, 95% CI 3.262-12.847, p=<0.001). In male patients with acute ischemic stroke and hypertriglyceridemia, an increased ischemic stroke mortality risk score was strongly associated with increased stroke severity (OR 6.474, p<0.001).
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