Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 2, 2026Stroke

Abstract WP113: Stroke in the Young: Sex Differences in Risk Factors, Etiologies, Acute Treatments, and Outcomes in a Nationwide Analysis

View Full Paper
Ask AI
Bookmark
Share

Key result

Young male sex is linked to ~21% higher stroke mortality and less IV thrombolysis than females.

Why the study?

Sex differences in vascular risk profiles, stroke etiologies, treatments, and outcomes in stroke in the young remain poorly understood.

Does male sex impact risk factors, etiologies, acute treatments, and hospital outcomes in young adults (18-50 years) with acute ischemic stroke?

Population

64,110 adult AIS patients aged 18-50 in the 2022 National Inpatient Sample

Comparison

Male vs female sex

Design

Nationwide retrospective cross-sectional study using survey-weighted analysis

Authors

EYEva YarskyCMCaleb McCardellASAhmed Sabra

Discussion

Loading...

Member takes

Overview

Males may face higher mortality and lower thrombolysis rates in young stroke; hypothesis-generating for sex-specific factors and needs prospective confirmation.

Key Points

  • To investigate the sex differences in risk factors, etiologies, acute treatments, and outcomes for young adults experiencing stroke.
  • Analyzed 2022 National Inpatient Sample data for acute ischemic stroke patients aged 18-50.
  • Stratified patients by sex and compared risk factors, treatments, and outcomes.
  • Utilized survey-weighted analysis for accurate results.
  • 54% of stroke cases were male; males had higher rates of smoking and some stroke etiologies.
  • Females showed lower rates of hypertension and hyperlipidemia but higher rates of obesity.
  • Males were 9% less likely to receive IV thrombolysis, and hospital mortality was higher in males by 21%.

Structured PICO

Does male sex impact risk factors, etiologies, acute treatments, and hospital outcomes in young adults (18-50 years) with acute ischemic stroke?

P
Population
64,110 adult acute ischemic stroke (AIS) patients aged 18-50 from the 2022 National Inpatient Sample
I
Intervention
Male sex
C
Comparator
Female sex
O
Outcome
In-hospital mortality, length of stay, and acute treatments (IV thrombolysis, mechanical thrombectomy)hard clinical

In young adults with acute ischemic stroke, males experience higher in-hospital mortality, more complications, and lower rates of IV thrombolysis compared to females.

Cite This Study

Yarsky et al. (2026) studied this question. Young males with acute ischemic stroke had a 21% higher risk of death and were 9% less likely to receive IV thrombolysis compared to females.

synapsesocial.com/papers/6980fd60c1c9540dea80f182https://doi.org/10.1161/str.57.suppl_1.wp113
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex differences in etiologies, risk factors, and outcomes among young adult patients with acute ischemic stroke2025 · 2 citations
  2. 2Sex-Specific Trends and Differences in Clinical Outcomes Among Young Patients With Ischemic Stroke2025
  3. 3Abstract TP112: Stroke In The Young: Etiologies and Hospital Outcomes in a National Cohort2026
  4. 4Impact of sex in stroke in the young2023 · 8 citations
  5. 5Abstract DP088: The Role of Sex and Age in Acute Ischemic Stroke2026