Key result
AIrd showed a stronger correlation with carotid-femoral pulse wave velocity (r=0.68, P<0.001) than radial augmentation index alone (r=0.61) for assessing arterial stiffness.
Why the study?
Does the novel index AIrd improve the assessment of arterial stiffness compared to AIr?
Cross-Sectional (n=120)
No
Does the novel index AIrd improve the assessment of arterial stiffness compared to AIr?
Effect estimate: r = 0.68
Absolute Event Rate: 0.68% vs 0.61%
p-value: p=<0.001
The novel index AIrd provides a stronger correlation with carotid-femoral pulse wave velocity and has fewer confounding factors than traditional radial augmentation index for assessing arterial stiffness.
AIrd may aid arterial stiffness assessment in cross-sectional data; leaves open prospective validation before clinical use.
Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index ( AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity ( cfPWV ). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index ( AI d ) with a weight α , to achieve better performance over AI r in assessing arterial stiffness. 120 subjects (43 ± 21 years old) were enrolled. The best-fit α is determined by the best correlation coefficient between AI rd and cfPWV . The performance of the method was tested using the 12-fold cross validation method. AI rd ( r = 0.68, P < 0.001) shows a stronger correlation with cfPWV and a narrower prediction interval than AI r ( r = 0.61, P < 0.001), AI d ( r = −0.17, P = 0.06), the central augmentation index ( AI c ) ( r = 0.61, P < 0.001) or AI c normalized for heart rate of 75 bpm ( r = 0.65, P < 0.001). Compared with AI r (age, P < 0.001; gender, P < 0.001; heart rate, P < 0.001; diastolic blood pressure, P < 0.001; weight, P = 0.001), AI rd has fewer confounding factors (age, P < 0.001; gender, P < 0.001). In conclusion, AI rd derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.
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Yao et al. (2017) conducted a cross-sectional in Arterial stiffness (n=120). Diastolic Augmentation Index combined with Radial Augmentation Index (AIrd) vs. Radial Augmentation Index (AIr) was evaluated on Correlation coefficient (r) with carotid-femoral pulse wave velocity (cfPWV) (r = 0.68, p=<0.001). AIrd showed a stronger correlation with carotid-femoral pulse wave velocity (r=0.68, P<0.001) than radial augmentation index alone (r=0.61) for assessing arterial stiffness.
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