Randomized trial demonstrates innate immunity and pathogenesis insights in porcine organoids, highlighting their potential as infection models.
Porcine respiratory CoV (PRCoV), a natural mutant of TGEV, shows striking pathogenetic similarities to human respiratory CoV infection and provides an interesting animal model for human respiratory CoVs, including SARS-CoV-2. The lack of an in vitro model recapitulating the complicated cellularity and structure of the porcine respiratory tract is a major roadblock for the study of PRCoV infection.
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Jiang et al. (2022) studied this question.
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