Key result
Diaphragm muscle fibers expressing the MHC(slow) isoform had significantly greater Ca(2+) sensitivity than fibers expressing fast MHC isoforms, associated with slow troponin complex isoforms.
Population
Single Triton-X-permeabilized rat diaphragm muscle (Dia(m)) fibers
Comparison
Expression of MHC isoform and slow isoforms of… vs Expression of fast MHC isoforms
Design
Preclinical
Authors
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May guide rodent diaphragm mechanics research; leaves open translation to human respiratory muscle disorders.
In rat diaphragm muscle fibers, calcium sensitivity is greater in fibers expressing slow MHC isoforms, which is associated with the expression of slow troponin complex isoforms.
Geiger et al. (1999) studied this question. MHC(slow) isoform expression vs. Fast MHC isoforms was evaluated on Ca(2+) concentration at which 50% maximal force was generated (pCa(50)). Diaphragm muscle fibers expressing the MHC(slow) isoform had significantly greater Ca(2+) sensitivity than fibers expressing fast MHC isoforms, associated with slow troponin complex isoforms.
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