Key result
Pregnancy-induced cardiac growth is associated with significant changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism.
Why the study?
Little is known about the molecular and cellular mechanisms contributing to pregnancy-induced cardiac growth, although evidence suggests changes in cardiac metabolism may contribute.
Pregnancy induces substantial metabolic, transcriptomic, and proteomic changes in the maternal heart, characterized by altered amino acid and lipid metabolism.
Supports hypothesis of metabolic reprogramming in maternal cardiac hypertrophy; leaves open clinical implications pending human validation.
Little is known of the underlying molecular and cellular mechanisms that contribute to pregnancy-induced cardiac growth. Several lines of evidence suggest that changes in cardiac metabolism may contribute. Here, we provide a comprehensive metabolic atlas of the metabolomic, proteomic, and transcriptomic changes occurring in the maternal heart. We show that pregnancy-induced cardiac growth is associated with changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism. Collectively, these results suggest that substantial metabolic changes occur in the maternal heart during and after pregnancy.
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Fulghum et al. (2022) studied Pregnancy-induced cardiac growth. Pregnancy vs. Nonpregnant mice was evaluated on Multi-omics profiling (metabolomic, transcriptomic, proteomic) of the maternal heart. Pregnancy-induced cardiac growth is associated with significant changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism.
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