Key result
A 1-standard deviation increase in 2-hour serum insulin was associated with a lower risk of cardiovascular disease death in older men without diabetes (HR 0.68; 95% CI 0.47-0.96; p=0.01).
Why the study?
Does hyperinsulinemia increase the risk of fatal cardiovascular disease in elderly men and women without diabetes?
Population
1,243 elderly men (n=538) and women (n=705) without diabetes from the Rancho Bernardo Study cohort
Comparison
Fasting and 2-hour serum insulin levels vs Lower insulin levels
Design
Cohort
Follow-up
5 years
Authors
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Hyperinsulinemia does not appear to raise fatal CVD risk in older adults without diabetes; leaves open inverse association in men for confirmation.
Cohort (n=1,243)
Does hyperinsulinemia increase the risk of fatal cardiovascular disease in elderly men and women without diabetes?
Hazard Ratio: 0.68 (95% CI 0.47–0.96)
p-value: p=0.01
Hyperinsulinemia is not associated with an increased risk of fatal cardiovascular disease in older adults without diabetes, and higher 2-hour insulin may even be inversely associated with CVD mortality in men.
Ferrara et al. (1994) conducted a cohort in Cardiovascular disease risk (n=1,243). Fasting and 2-hour serum insulin levels vs. Lower insulin levels was evaluated on Cardiovascular disease death (HR 0.68, 95% CI 0.47-0.96, p=0.01). A 1-standard deviation increase in 2-hour serum insulin was associated with a lower risk of cardiovascular disease death in older men without diabetes (HR 0.68; 95% CI 0.47-0.96; p=0.01).
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