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A coupled electromechanics model of a single cardiac cell was developed to interpret experimental tests and compare with other models of myofilament mechanics.
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This study presents a comprehensive computational model of cardiac cellular electromechanics that integrates multiple kinetic and mechanical properties with cell electrophysiology.
A coupled electromechanics model of a single cardiac cell is used to interpret a wide variety of experimental tests and is compared to a limited extent (since no other cardiac model dealing with the full range of mechanical tests is available) with other models of myofilament mechanics. We consider the passive elasticity of the cell, troponin–C–calcium binding kinetics, thin filament kinetics, the length dependence of steady–state tension, cross–bridge kinetics, and the coupling of mechanics to cell electrophysiology (the Noble 98 model) via the calcium transient.
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Nickerson et al. (2001) studied Cardiac cellular electromechanics. Coupled electromechanics model vs. Other models of myofilament mechanics was evaluated. A coupled electromechanics model of a single cardiac cell was developed to interpret experimental tests and compare with other models of myofilament mechanics.
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