A new kinetic model successfully simulates calcium-mechanics coupling in myocardium contraction, capturing the Frank-Starling law and load-dependent relaxation.
Answers are grounded in this paper and cite their sources.
May guide computational models of myocardial contraction; leaves open translation from animal data to human application.
A kinetic model of cardiac muscle contraction is suggested. It is based on our earlier simplified model of the kinetics of the actin-myosin interaction. We examined the kinetics of formation of calcium-troponin complexes which open the binding sites on actin for myosin heads. The model also takes into account the cooperativity of this process and the influence of myosin heads on it. It was shown that with proper choice of its parameters the model appropriately describes the dependence of myocardium activation on sarcomeres length that underlies the Frank-Starling law of the heart. The model fits both steady-state experiments on myocardial specimens with permeable membrane and twitch contractions of intact cardiac muscle. It also describes well the myocardium load-dependent relaxation.
No takes yet. Share an insight, caveat, or question.
Fyodor A. Syomin (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: