January 4, 2010The Open Physiology JournalOpen Access

Simulation Analysis of Cardiac Muscle Isotonic Contractions at Different Pre- and Afterloads

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Population

Computational model of cardiac muscle contraction incorporating troponin C, troponin I, tropomyosin…

Design

Preclinical

Authors

NSNatalie SchneiderUniversity of Kassel AAAkira AmanoRitsumeikan University

Discussion

Member takes

Implication

Animal simulation data remain hypothesis-generating; leaves open translation of load-dependent contraction mechanisms to clinical cardiology.

Structured PICO

Population

Computational model of cardiac muscle contraction incorporating troponin C, troponin I, tropomyosin, Frank-Starling mechanism, and cross-bridge mechanics, validated against guinea pig myocyte data

Intervention

Simulation of afterloaded isotonic contractions at various preloads and afterloads

Outcome

Load and sarcomere length-dependence of thin filament and cross-bridge kinetics during muscle shortening and relaxation

A novel computational model incorporating detailed thin filament activation provides new insights into the regulatory mechanisms of cardiac muscle contraction and relaxation under varying loads.

Cite This Study

Schneider et al. (2010) studied this question.

synapsesocial.com/papers/6a2147d2f69db56553c3d478 https://doi.org/10.2174/1874360900902010018

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Implication

Animal simulation data remain hypothesis-generating; leaves open translation of load-dependent contraction mechanisms to clinical cardiology.

Simulation Analysis of Cardiac Muscle Isotonic Contractions at Different Pre- and Afterloads

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Simulation Analysis of Cardiac Muscle Isotonic Contractions at Different Pre- and Afterloads

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider