Why the study?
Are depressive symptoms independently associated with adverse cardiovascular outcomes in patients with a history of acute coronary syndrome?
Population
1130 participants of the LIPID Study with a history of acute myocardial infarction or unstable angina
Comparison
Presence of depressive symptoms vs Absence of depressive symptoms
Design
Cohort
Follow-up
median 8.1 years
Authors
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No independent association after adjustment; leaves open confounding by symptoms and psychosocial factors, challenging prior causal assumptions.
Are depressive symptoms independently associated with adverse cardiovascular outcomes in patients with a history of acute coronary syndrome?
The previously observed association between depression and cardiovascular events in post-ACS patients may not be causal, but rather confounded by underlying cardiovascular symptoms and psychosocial factors.
Ralph Stewart (2003) studied this question.
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