Key result
Direct RT-qPCR without RNA extraction for SARS-CoV-2 detection achieved a sensitivity of 95.69%, negative predictive value of 99.9%, accuracy of 99.35%, and AUC of 0.978.
Why the study?
Does direct RT-qPCR without RNA extraction accurately detect SARS-CoV-2 variants?
Design
Other
Authors
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May support high-throughput SARS-CoV-2 testing; leaves open prospective validation for variants and cost-effectiveness.
Does direct RT-qPCR without RNA extraction accurately detect SARS-CoV-2 variants?
A novel direct RT-qPCR method without RNA extraction provides highly accurate, cost-effective, and high-throughput detection of SARS-CoV-2.
Yang et al. (2022) studied SARS-CoV-2. Direct RT-qPCR without RNA extraction was evaluated on Analytical sensitivity. Direct RT-qPCR without RNA extraction for SARS-CoV-2 detection achieved a sensitivity of 95.69%, negative predictive value of 99.9%, accuracy of 99.35%, and AUC of 0.978.
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