Understanding the pathogenetic mechanisms of type 2 diabetes on the myocardium in ischemic heart disease is crucial for selecting appropriate pathogenetic therapies.
The list of the most significant social problems for a long time is leaded by the association of type 2 diabetes and ischemic heart disease. Despite the good progress in the diagnosis and treatment of these two pathologies, in case of their interaction some clinical signs acquire atypical course. In patients with comorbid pathology it is characterized by painless, rapidly progressing course of coronary events. In type 2 diabetes mellitus, glucose toxicity and lipotoxicity contribute to myocardial dysfunction, vegetative innervation is disrupted, and specific myocardial damage — diabetic cardiopathy also develops. Diabetes contributes the progression of atherosclerosis and myocardial ischemia, and this increase the severity of the cardiovascular pathology. Understanding the pathogenetic mechanisms of the diabetes effect on the myocardium of patients with ischemic disease allows identifying of key points for the selection of pathogenetic therapy.
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Ворожцова et al. (2018) studied this question.
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