Key result
Chronic hyperglycemia drives accelerated atherosclerosis and impaired myocardial perfusion in type 2 diabetes.
Why the study?
Diabetic angiopathy and ischemic heart disease are leading causes of morbidity and mortality in type 2 diabetes mellitus, with unclear pathogenic mechanisms linking them.
Understanding the pathogenic mechanisms of diabetic angiopathy is essential for the early diagnosis and prevention of ischemic heart disease in patients with type 2 diabetes.
Supports glycemic vigilance for IHD prevention in T2D; confirms angiopathy mechanisms but leaves targeted interventions open for trials.
Type 2 diabetes mellitus (T2DM) is one of the most common chronic metabolic disorders associated with severe cardiovascular complications. Among these complications, diabetic angiopathy and ischemic heart disease (IHD) occupy a leading position in morbidity and mortality worldwide. Chronic hyperglycemia contributes to vascular endothelial damage, oxidative stress, inflammation, and accelerated atherosclerosis, all of which play critical roles in the pathogenesis of coronary artery disease. Diabetic angiopathy affects both microvascular and macrovascular circulation, leading to impaired myocardial perfusion and increased risk of ischemic events. This article discusses the major pathogenic mechanisms linking diabetic angiopathy with the development of ischemic heart disease in patients with type 2 diabetes mellitus. Understanding these mechanisms is essential for early diagnosis, prevention, and effective therapeutic strategies aimed at reducing cardiovascular complications in diabetic patients.
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Jo'rayeva Gulhayo Jalol kizi (2026) conducted a review in Type 2 diabetes mellitus and ischemic heart disease. Diabetic angiopathy was evaluated. Chronic hyperglycemia and diabetic angiopathy contribute to vascular damage and accelerated atherosclerosis, leading to impaired myocardial perfusion and ischemic heart disease in type 2 diabetes.
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