Key result
MYH11 gene mutation in young asymptomatic adults was associated with significantly lower aortic compliance (0.84 vs 2.03 mm2/mmHg) and higher pulse wave velocity compared to nonmutated relatives.
Why the study?
Does MRI assessment of aortic compliance and pulse wave velocity detect early aortic impairment in young asymptomatic individuals with MYH11 mutation compared to nonmutated relatives?
Cross-Sectional (n=29)
Does MRI assessment of aortic compliance and pulse wave velocity detect early aortic impairment in young asymptomatic individuals with MYH11 mutation compared to nonmutated relatives?
Absolute Event Rate: 0.84% vs 2.03%
MRI-derived aortic compliance and pulse wave velocity can detect early aortic impairment in asymptomatic MYH11 mutation carriers before aortic enlargement occurs.
Authors
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May support MRI for early aortic assessment in asymptomatic MYH11 carriers; leaves open need for longitudinal outcome validation.
Lalande et al. (2008) conducted a cross-sectional in MYH11 gene mutation (n=29). MYH11 gene mutation vs. Nonmutated relatives was evaluated on Aortic compliance (mm2/mmHg). MYH11 gene mutation in young asymptomatic adults was associated with significantly lower aortic compliance (0.84 vs 2.03 mm2/mmHg) and higher pulse wave velocity compared to nonmutated relatives.
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