Key result
A low basal inferolateral regional uptake ratio (≤57%) on MP-SPECT predicted worse prognosis for overall mortality or heart failure hospitalization after CRT (log-rank P=0.006).
Why the study?
Does basal inferolateral scar burden determined by automatic analysis of MP-SPECT predict long-term prognosis and volume response in patients undergoing cardiac resynchronization therapy?
Population
51 consecutive patients eligible to undergo 99mTc-MIBI myocardial perfusion SPECT both at baseline and 6…
Design
Cohort
Follow-up
median 36.1 months
Authors
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May refine post-CRT risk stratification; leaves open prospective validation for scar-guided selection.
Observational (n=51)
Does basal inferolateral scar burden determined by automatic analysis of MP-SPECT predict long-term prognosis and volume response in patients undergoing cardiac resynchronization therapy?
p-value: p=0.006
Automatic quantification of basal inferolateral scar burden using MP-SPECT can predict poor volume response and long-term prognosis in patients receiving cardiac resynchronization therapy.
Morishima et al. (2016) conducted an observational in Heart failure requiring cardiac resynchronization therapy (n=51). Basal inferolateral scar burden (low regional uptake ratio ≤57%) vs. High regional uptake ratio (>57%) was evaluated on Composite of overall mortality or first hospitalization for worsening heart failure (p=0.006). A low basal inferolateral regional uptake ratio (≤57%) on MP-SPECT predicted worse prognosis for overall mortality or heart failure hospitalization after CRT (log-rank P=0.006).
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