Key result
Combined assessment of MP-SPECT and LV mechanical dyssynchrony predicted cardiac resynchronization therapy response with a sensitivity of 77.8% and specificity of 91.2%.
Why the study?
Does combined assessment of left ventricular mechanical dyssynchrony and myocardial perfusion by MP-SPECT predict response to CRT in patients with non-ischemic cardiomyopathy?
Observational (n=43)
Does combined assessment of left ventricular mechanical dyssynchrony and myocardial perfusion by MP-SPECT predict response to CRT in patients with non-ischemic cardiomyopathy?
Combined assessment of left ventricular mechanical dyssynchrony and myocardial perfusion using MP-SPECT can effectively predict CRT response in patients with non-ischemic cardiomyopathy.
May aid CRT selection in non-ischemic cardiomyopathy; hypothesis-generating, needs prospective validation before practice change.
Background The aim of this study was to investigate the use of imaging techniques to predict the response to cardiac resynchronization therapy (CRT) in patients with non‐ischemic cardiomyopathy (NICM) by simultaneous assessment of left ventricular (LV) dyssynchrony and myocardial perfusion in a single nuclear scan of the heart. Methods Patients indicated for CRT device implantation underwent a resting myocardial perfusion assessment with single photon emission computed tomography (MP‐SPECT) examination using technetium‐99 m methoxyisobutylisonitrile prior to device implantation. CardioGRAF and cardioBull software (FUJIFILM RI Pharma, Tokyo, Japan) were used to analyze the LV mechanical dyssynchrony and myocardial viability, respectively. Patient follow‐ups were performed at 6 months after device implantation. CRT response was defined as a ≥10% decrease in the LV end systolic volume. Results A total of 43 patients with NICM were analyzed. Using the cutoff points of 6.2 for the dyssynchrony index and 66% for LV myocardial perfusion, the combined indices predicted CRT response with a sensitivity of 77.8% and specificity of 91.2%. Conclusion Combined assessment of MP‐SPECT and a measure of LV mechanical dyssynchrony showed good predictive ability in patients with non‐ischemic heart failure.
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Keida et al. (2013) conducted an observational in Non-ischemic cardiomyopathy (n=43). Combined assessment of MP-SPECT and LV mechanical dyssynchrony was evaluated on CRT response (defined as a ≥10% decrease in the LV end systolic volume). Combined assessment of MP-SPECT and LV mechanical dyssynchrony predicted cardiac resynchronization therapy response with a sensitivity of 77.8% and specificity of 91.2%.
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