Key result
Intravenous injection of PBS-boiled rat atrial extract significantly increased urinary sodium excretion by 672 ± 307% (P < 0.05) compared to PBS alone or ventricular extract.
Population
Anesthetized nondiuretic (not hydrated) rats
Comparison
Intravenous injection of PBS-boiled or… vs Intravenous injection of PBS alone or…
Design
Preclinical
Follow-up
10 minutes
Authors
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Hypothesis-generating in rats; leaves open translation of atrial natriuretic activity to human volume regulation.
p-value: p=<0.05
Rat atrial heart tissue contains a specific natriuretic substance that profoundly increases sodium and water excretion, distinct from previously reported natriuretic factors.
Trippodo et al. (1982) studied this question. PBS-boiled atrial extract vs. PBS alone or ventricular extract was evaluated on Urinary sodium excretion (UNaV) (p=<0.05). Intravenous injection of PBS-boiled rat atrial extract significantly increased urinary sodium excretion by 672 ± 307% (P < 0.05) compared to PBS alone or ventricular extract.
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