Key result
Higher predialysis systolic blood pressure variability was associated with an increased risk of all-cause mortality (HR 1.18; 95% CI 1.13 to 1.22 per 1 SD increase) in hemodialysis patients.
Why the study?
Does higher predialysis systolic blood pressure variability increase the risk of mortality and cardiovascular events in incident hemodialysis patients?
Cohort (n=11,291)
Does higher predialysis systolic blood pressure variability increase the risk of mortality and cardiovascular events in incident hemodialysis patients?
Hazard Ratio: 1.18 (95% CI 1.13–1.22)
Predialysis systolic blood pressure variability is an important, potentially modifiable risk factor for death and cardiovascular outcomes in incident hemodialysis patients.
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May inform risk stratification in hemodialysis; leaves open whether targeting variability improves outcomes.
Shafi et al. (2014) conducted a cohort in Hemodialysis (n=11,291). Predialysis systolic BP variability vs. Lower BP variability (per 1 SD increase) was evaluated on All-cause mortality (HR 1.18, 95% CI 1.13 to 1.22). Higher predialysis systolic blood pressure variability was associated with an increased risk of all-cause mortality (HR 1.18; 95% CI 1.13 to 1.22 per 1 SD increase) in hemodialysis patients.
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