Key result
Hospitalization for acute myocardial infarction in 1996 was associated with a decrease in one-year mortality to 19.7% compared to 26.3% in 1986 (p < 0.05).
Why the study?
Did one-year mortality after acute myocardial infarction improve between 1986 and 1996 due to changes in therapy?
Observational
Did one-year mortality after acute myocardial infarction improve between 1986 and 1996 due to changes in therapy?
Absolute Event Rate: 19.7% vs 26.3%
p-value: p=< 0.05
One-year mortality after acute myocardial infarction significantly decreased between 1986 and 1996 in Iceland, partially driven by the adoption of evidence-based therapies such as aspirin, beta-blockers, and thrombolytics.
Declining post-MI mortality supports evolving care; leaves open causal roles of specific therapies without randomization.
During the last decade the treatment of patients with acute myocardial infarction (AMI) has changed dramatically. In order to evaluate the overall impact of these changes on mortality and morbidity, we collected data on all patients hospitalized for AMI in Reykjavik, Iceland, during the calendar years of 1986 and 1996. Demographical characteristics of AMI patients did not change significantly between study periods. One-year mortality decreased from 26.3 to 19.7% (p < 0.05). Patients discharged with aspirin or beta-antagonists as well as those who received thrombolytic therapy had decreased 1-year mortality both years. Patients discharged with diuretics, digoxin or antiarrhythmics had increased 1-year mortality. We conclude that the 25% reduction in 1-year mortality is partially due to changes in therapy.
No takes yet. Share an insight, caveat, or question.
Kristjánsson et al. (1999) conducted an observational in Acute myocardial infarction (AMI). Hospitalization for AMI in 1996 vs. Hospitalization for AMI in 1986 was evaluated on One-year mortality (p=< 0.05). Hospitalization for acute myocardial infarction in 1996 was associated with a decrease in one-year mortality to 19.7% compared to 26.3% in 1986 (p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: