Key result
Anticholinesterase treatment in Alzheimer's disease patients was associated with significantly higher vortex formation time compared to nontreated patients, suggesting cardioprotective effects.
Why the study?
Do acetylcholinesterase inhibitors improve vortex formation time in patients with Alzheimer's disease?
Case-Control (n=47)
Do acetylcholinesterase inhibitors improve vortex formation time in patients with Alzheimer's disease?
Acetylcholinesterase inhibitors may provide cardioprotective effects in Alzheimer's disease patients by improving diastolic filling parameters such as vortex formation time.
May suggest diastolic benefits in AD; hypothesis-generating for cardioprotection, requiring prospective validation.
BACKGROUND/AIM: Traditional risk factors, like impaired transmitral flow in diastolic filling [vortex formation time (VFT) as echocardiographic parameter], contribute to Alzheimer's disease (AD). Moreover, we observed that acetylcholinesterase inhibitors provide a significant cardioprotection. We assessed the pathogenetic role of VFT as early cardiovascular risk factor in 23 AD patients and 24 controls. RESULTS: The results showed no statistical difference between the two groups, but the VFT values were significantly lower in nontreated AD patients, and higher value were observed in AD patients treated with anticholinesterases. CONCLUSIONS: The results support the beneficial effects of anticholinesterases on the cardiovascular system of AD patients. Thus, the transition to evidence-based medicine and an in vivo model of cardiomyocytes might strengthen these results.
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Monacelli et al. (2014) conducted a case-control in Alzheimer's disease (n=47). Anticholinesterases vs. Nontreated Alzheimer's disease patients was evaluated on Vortex formation time (VFT). Anticholinesterase treatment in Alzheimer's disease patients was associated with significantly higher vortex formation time compared to nontreated patients, suggesting cardioprotective effects.
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