Why the study?
Does eptastigmine improve autonomic cardiac dysfunction in patients with Alzheimer disease?
Population
12 patients with probable Alzheimer disease and 10 healthy controls.
Comparison
Oral eptastigmine for 1 month. vs Healthy controls and pre-treatment baseline.
Design
Cohort
Follow-up
1 month
Authors
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May support short-term HRV normalization with eptastigmine in AD; leaves open effects on clinical cardiac outcomes.
Does eptastigmine improve autonomic cardiac dysfunction in patients with Alzheimer disease?
Cholinesterase inhibitor treatment with eptastigmine may normalize aspects of autonomic cardiac dysfunction in patients with Alzheimer disease.
Giubilei et al. (1998) studied this question.
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