Key result
Alzheimer's disease patients had significantly depressed R-R interval variation during rest (6.4% vs 7.5%, p<0.02) and deep breathing compared to controls, indicating mild autonomic impairment.
Why the study?
Are cardiovascular autonomic functions impaired in patients with Alzheimer's disease compared to age-matched controls?
Population
23 patients with Alzheimer's disease (AD) and 23 age-matched control subjects (total n=46)
Design
Case-control
Authors
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May merit autonomic monitoring in Alzheimer's; hypothesis-generating for cardiovascular risk links.
Case-Control (n=46)
Are cardiovascular autonomic functions impaired in patients with Alzheimer's disease compared to age-matched controls?
Absolute Event Rate: 6.4% vs 7.5%
p-value: p=<0.02
Alzheimer's disease patients exhibit mildly impaired autonomic functions, primarily in vagal parasympathetic activity, and have lower systolic blood pressure compared to age-matched controls.
Wang et al. (1994) conducted a case-control in Alzheimer's disease (n=46). Alzheimer's disease (exposure) vs. Age-matched controls was evaluated on R-R interval variation (RRIV) during rest (p=<0.02). Alzheimer's disease patients had significantly depressed R-R interval variation during rest (6.4% vs 7.5%, p<0.02) and deep breathing compared to controls, indicating mild autonomic impairment.
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