Key result
Alzheimer's disease was associated with altered sympathovagal balance toward relative parasympathetic depression and sympathetic exacerbation in the supine posture (P=0.05).
Why the study?
Does Alzheimer's disease alter cardiac sympathovagal modulation evaluated by short-term heart interval variability compared to healthy individuals?
Population
46 subjects, including 22 with Alzheimer's disease and 24 healthy individuals.
Comparison
Alzheimer's disease (exposure) vs Healthy individuals
Design
Case-control
Authors
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Supports autonomic imbalance in Alzheimer's; leaves open prognostic or therapeutic value of HRV assessment.
Observational (n=46)
Does Alzheimer's disease alter cardiac sympathovagal modulation evaluated by short-term heart interval variability compared to healthy individuals?
p-value: p=0.05
Toledo et al. (2008) conducted an observational in Alzheimer's disease (n=46). Alzheimer's disease vs. Healthy individuals was evaluated on Time- and frequency-domain variability of 5-min R-R interval series in supine and standing positions (p=0.05). Alzheimer's disease was associated with altered sympathovagal balance toward relative parasympathetic depression and sympathetic exacerbation in the supine posture (P=0.05).
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