Why the study?
Does Alzheimer's disease alter sympathetic and parasympathetic cardiac innervation compared to normal controls?
Population
Patients with Alzheimer's disease and normal volunteer controls
Comparison
Alzheimer's disease (observational exposure) vs Normal volunteer controls
Design
Case-control
Authors
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AD-associated HRV changes suggest autonomic imbalance; hypothesis-generating and should not yet alter practice.
Does Alzheimer's disease alter sympathetic and parasympathetic cardiac innervation compared to normal controls?
Patients with Alzheimer's disease exhibit a relatively hypersympathetic and hypoparasympathetic state compared to normal controls, as measured by heart rate variability.
Aharon‐Peretz et al. (1992) studied this question.
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