Key result
Patients with Alzheimer's dementia and mild cognitive impairment showed higher cerebral autoregulation during orthostatic challenges (autoregulatory index 4.56 and 4.59) than controls (3.71; P=0.011).
Why the study?
Are cerebral autoregulation and baroreflex sensitivity impaired in patients with dementia and mild cognitive impairment due to Alzheimer disease compared to controls?
Population
137 participants including 53 patients with dementia, 37 patients with mild cognitive impairment due to…
Comparison
Orthostatic challenges using repeated… vs Controls
Design
Cross-sectional
Authors
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Preserved autoregulation in Alzheimer disease may not increase antihypertensive risks; hypothesis-generating and requires prospective validation.
Observational (n=137)
Are cerebral autoregulation and baroreflex sensitivity impaired in patients with dementia and mild cognitive impairment due to Alzheimer disease compared to controls?
Absolute Event Rate: 4.56% vs 3.71%
p-value: p=0.011
Cerebral autoregulation and baroreflex sensitivity are preserved in patients with mild cognitive impairment and dementia due to Alzheimer disease, suggesting these mechanisms do not inherently increase the risks of antihypertensive treatment in this population.
Heus et al. (2018) conducted an observational in Alzheimer disease (dementia and mild cognitive impairment) (n=137). Orthostatic challenges (repeated sit-to-stand maneuvers) vs. Healthy controls was evaluated on Autoregulatory index during orthostatic challenges (p=0.011). Patients with Alzheimer's dementia and mild cognitive impairment showed higher cerebral autoregulation during orthostatic challenges (autoregulatory index 4.56 and 4.59) than controls (3.71; P=0.011).
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