Why the study?
Cerebral autoregulation protects brain perfusion against changes in blood pressure, and its impairment may contribute to the development of Alzheimer's disease.
Is the efficacy of cerebral autoregulation reduced in older adults with amnestic mild cognitive impairment?
Is the efficacy of cerebral autoregulation reduced in older adults with amnestic mild cognitive impairment?
Reduced efficacy of cerebral autoregulation in amnestic mild cognitive impairment suggests cerebrovascular dysfunction may be an underlying pathophysiological mechanism for Alzheimer's disease development.
Cerebral autoregulation is a fundamental regulatory mechanism to protect brain perfusion against changes in blood pressure that, if impaired, may contribute to the development of Alzheimer's disease. Using a linear mixed model, we demonstrated that the efficacy of cerebral autoregulation, assessed during stepwise changes in arterial pressure, was reduced in individuals with amnestic mild cognitive impairment, a prodromal stage of Alzheimer's disease. These findings support the hypothesis that cerebrovascular dysfunction may be an important underlying pathophysiological mechanism for the development of clinical Alzheimer's disease.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: