Altered Cerebral Hemodynamics in Early Alzheimer Disease: A Pilot Study Using Transcranial Doppler
Why the study?
Does mild Alzheimer's disease alter cerebral hemodynamics compared to cognitively normal controls?
Population
17 subjects total, comprising 9 patients with mild Alzheimer's disease and 8 cognitively normal controls…
Comparison
Assessment of cerebral hemodynamics using… vs Cognitively normal controls matched for age…
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Altered hemodynamics in mild AD support vascular involvement; hypothesis-generating and should not yet change practice.
Structured PICO
Does mild Alzheimer's disease alter cerebral hemodynamics compared to cognitively normal controls?
P
Population
17 subjects total, comprising 9 patients with mild Alzheimer's disease (AD) and 8 cognitively normal controls matched for age.
I
Intervention
Assessment of cerebral hemodynamics using steady-state cerebral blood flow velocity (CBFV, transcranial Doppler), blood pressure (BP, Finapres), and cerebrovascular resistance index (BP/CBFV) at rest, during standing up after squat, and during repeated squat-stand maneuvers.
C
Comparator
Cognitively normal controls matched for age undergoing the same hemodynamic assessments.
O
Outcome
Cerebral hemodynamics (steady-state cerebral blood flow velocity, blood pressure, cerebrovascular resistance index, and dynamic cerebral autoregulation).surrogate
Early-stage Alzheimer's disease is associated with altered cerebral hemodynamics, including lower cerebral blood flow velocity and higher cerebrovascular resistance, despite preserved dynamic cerebral autoregulation.
Cite This Study
Claassen et al. (2009) studied this question.