Why the study?
Does transcranial Doppler sonography detect differences in MCA blood flow velocities between Alzheimer's disease patients and healthy controls?
Does transcranial Doppler sonography detect differences in MCA blood flow velocities between Alzheimer's disease patients and healthy controls?
Transcranial Doppler sonography reveals slower MCA blood flow velocities in Alzheimer's disease patients, which correlate with the laterality of cognitive impairment.
TCD-detected MCA hypoperfusion in AD is hypothesis-generating; does not support diagnostic use or practice change without prospective validation.
Transcranial Doppler sonography examination of 23 patients with Alzheimer''s disease (AD) showed significantly slower blood flow velocities, bilaterally, in the middle cerebral arteries (MCAs) than in 10 healthy controls. The asymmetries of velocities in MCA were positively correlated with asymmetries of cognitive impairment, but not with global severity or duration of disease. Patients with prevalent left hemispheric neuropsychological dysfunction showed significantly slower blood flow in the left MCA, while the opposite pattern was observed in patients with prevalent right hemisphere dysfunction. The possibility that these findings are an expression of the reduction of cerebral blood flow and metabolism shown in AD by emission tomography studies is discussed.
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Bressi et al. (1992) studied this question.
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