Why the study?
Do patients with Alzheimer's disease exhibit autonomic dysfunction compared to healthy controls?
Do patients with Alzheimer's disease exhibit autonomic dysfunction compared to healthy controls?
Patients with Alzheimer's disease exhibit signs of autonomic dysfunction affecting both parasympathetic and sympathetic systems.
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Suggests autonomic dysfunction in Alzheimer's; hypothesis-generating and requires longitudinal studies before clinical relevance is clear.
Twenty-nine patients fitting the NINCDS-ADRDA criteria of Alzheimer's disease participated in a study of autonomic functions. A number of tests on parasympathetic and sympathetic functions were made. Eighteen of the patients were tested a second time one year later. Fifteen healthy subjects with no family history of dementia disorders served as controls. Compared to the controls, the patients showed signs suggesting autonomic dysfunction affecting parasympathetic, as well as vasomotor sympathetic, functions.
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Algotsson et al. (1995) studied this question.
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