Key result
Spironolactone added to standard treatment significantly reduced liver size and weight (P<0.01) and respiratory rate (P<0.05) compared to potassium supplements in infants with heart failure.
Why the study?
Does spironolactone improve clinical signs of congestive heart failure in infants with congenital heart disease?
Does spironolactone improve clinical signs of congestive heart failure in infants with congenital heart disease?
p-value: p=<0.01
The addition of spironolactone to standard therapy with digoxin and chlorothiazide hastens and enhances the clinical response in infants with congestive heart failure secondary to congenital heart disease.
May reduce signs of heart failure in infants; leaves open confirmation by randomized trials before practice change.
The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age. All received digoxin and chlorothiazide. In addition, group A (n = 10) was given supplements of potassium and group B (n = 11) received spironolactone. Daily clinical observations of vital signs, weight, hepatomegaly, and vomiting were recorded. Paired t test analysis showed significant reduction in liver size and weight (P less than 0.01) and respiratory rate (P less than 0.05) in group B, and less significant decreases in group A. The incidence of vomiting was slightly lower in group B. We conclude that the addition of spironolactone hastens and enhances the response to standard treatment with digoxin and chlorothiazide in infants with congestive heart failure.
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Hobbins et al. (1981) studied Congestive heart failure secondary to congenital heart disease (n=21). Spironolactone vs. Potassium supplements was evaluated on Reduction in liver size, weight, and respiratory rate (p=<0.01). Spironolactone added to standard treatment significantly reduced liver size and weight (P<0.01) and respiratory rate (P<0.05) compared to potassium supplements in infants with heart failure.
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