Key result
Right ventricular pacing in patients with congenital heart block was significantly associated with the development of cardiomyopathy (P=0.021), with no unpaced patients developing the condition.
Why the study?
Characterization of pacing-induced cardiomyopathy after chronic RV pacing is often complicated by pre-existing cardiomyopathy in adults, prompting investigation in patients with congenital heart block without confounding pre-existing conditions.
Does right ventricular pacing increase the risk of developing cardiomyopathy in patients with congenital heart block?
Population
42 patients with congenital heart block and baseline LVEF ≥50%
Comparison
Paced vs nonpaced patients
Design
Retrospective cohort analysis
Follow-up
Median 35 years from birth (median 6.7 years at institution)
Authors
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RV pacing was associated with cardiomyopathy in congenital heart block; leaves open whether alternative pacing reduces risk.
Cohort (n=42)
No
Does right ventricular pacing increase the risk of developing cardiomyopathy in patients with congenital heart block?
p-value: p=0.021
In patients with congenital heart block and normal baseline function, right ventricular pacing is associated with a significantly increased risk of developing pacing-induced cardiomyopathy.
Rangavajla et al. (2021) conducted a cohort in Congenital heart block (n=42). Right ventricular pacing vs. No pacing was evaluated on Development of cardiomyopathy (LVEF <50%) (p=0.021). Right ventricular pacing in patients with congenital heart block was significantly associated with the development of cardiomyopathy (P=0.021), with no unpaced patients developing the condition.
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