Why the study?
Does albuminuria predict cardiovascular outcomes and does losartan reduce albuminuria more than atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy?
Does albuminuria predict cardiovascular outcomes and does losartan reduce albuminuria more than atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy?
In patients with diabetes, hypertension, and left ventricular hypertrophy, losartan reduces albuminuria more effectively than atenolol, which partially explains its superior cardiovascular benefits.
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May partly mediate losartan CV benefit via greater UACR reduction in diabetic LVH; leaves open causal confirmation in RCTs.
Ibsen et al. (2006) studied this question.
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