Key result
Blood collection in evacuated glass tubes resulted in unpredictably shorter APTT compared to plastic tubes (r = 0.04 to 0.25), making them hazardous for monitoring heparin therapy.
Why the study?
Does blood collection in evacuated glass tubes affect APTT results in patients on heparin therapy compared to plastic tubes?
Observational
Does blood collection in evacuated glass tubes affect APTT results in patients on heparin therapy compared to plastic tubes?
Effect estimate: r = 0.04 to 0.25
Evacuated glass tubes can cause inappropriately short APTT results due to substances eluted from rubber stoppers, making them hazardous for monitoring heparin therapy.
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Clinicians should verify tube material before APTT-based heparin monitoring; this Level 4 evidence leaves open the need for prospective validation.
Heyns et al. (1981) conducted an observational in Venous thromboembolism. Evacuated glass tubes vs. Plastic or siliconised glass tubes was evaluated on Activated partial thromboplastin times (APTT) (r = 0.04 to 0.25). Blood collection in evacuated glass tubes resulted in unpredictably shorter APTT compared to plastic tubes (r = 0.04 to 0.25), making them hazardous for monitoring heparin therapy.
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