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A case of keratoacanthoma, preceding four primary malignant tumours without metastasis, is presented. Two similar cases from the literature with two and three multiple primary carcinomas, are reviewed. They all have the following findings in common: (1) keratoacanthoma, (2) adenocarcinoma of the colon, (3) additional primary malignant tumour or tumours, and (4) absent or delayed metastasis.
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Slobodan Poleksic (1974) studied this question.
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