Key result
AT2 receptor overexpression in transgenic mice significantly reduced LV myocyte diameter and interstitial collagen following 70 days of aortic banding compared with nontransgenic mice.
Why the study?
Does selective overexpression of AT2 receptors in ventricular myocytes modify chronic pressure overload-induced cardiac hypertrophy in mice?
Does selective overexpression of AT2 receptors in ventricular myocytes modify chronic pressure overload-induced cardiac hypertrophy in mice?
AT2 receptor overexpression modifies the pathological hypertrophic response to aortic banding in transgenic mice, reducing myocyte diameter and collagen but increasing LV dimensions.
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AT2 overexpression attenuates hypertrophic remodeling in pressure-overloaded mice; hypothesis-generating and leaves open translation to human heart failure therapies.
Yan et al. (2008) studied Chronic pressure overload-induced cardiac hypertrophy. AT2 receptor overexpression vs. Nontransgenic mice (NTG-AS) was evaluated on LV myocyte diameter and interstitial collagen. AT2 receptor overexpression in transgenic mice significantly reduced LV myocyte diameter and interstitial collagen following 70 days of aortic banding compared with nontransgenic mice.
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