Key result
A type 3 vaccine-derived poliovirus isolated from an infant with hand, foot, and mouth disease in China exhibited reversion mutations at known attenuation sites and recombination with Sabin 1.
Why the study?
Oral polio vaccine is genetically unstable and can mutate into vaccine-derived polioviruses, which are currently mainly detected through AFP and sewage surveillance.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
The isolation of an independently evolved type 3 vaccine-derived poliovirus from a patient with HFMD highlights the importance of broad enteroviral disease surveillance for detecting silent poliovirus circulation.
BACKGROUND: The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance. METHODS: In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed. RESULT: The strain had reversion mutations at the known attenuation site 5' non-coding region and recombined with Sabin1, Phylogenetic analysis of the VP1 coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally. CONCLUSION: It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2025) conducted a case report in Hand, foot, and mouth disease (HFMD) / Vaccine-derived poliovirus infection (n=1). Type 3 vaccine-derived poliovirus (VDPV3) was evaluated on Genetic characterization and phylogenetic analysis of the isolated poliovirus strain. A type 3 vaccine-derived poliovirus isolated from an infant with hand, foot, and mouth disease in China exhibited reversion mutations at known attenuation sites and recombination with Sabin 1.
Synapse has enriched 10 related papers. Consider them for comparative context: