Key result
The NOS3 (rs2070744) C-allele was significantly associated with essential arterial hypertension severity, characterized by a 40.88% decrease in NO metabolites and reduced NOS3 transcription activity compared to the TT-genotype.
Why the study?
The study aimed to clarify endothelial function biomarkers and carotid intima-media thickness changes in relation to GNB3 (rs5443) and NOS3 (rs2070744) gene polymorphisms in essential arterial hypertension.
Does NOS3 (rs2070744) and GNB3 (rs5443) gene polymorphism correlate with endothelial function impairment and carotid IMT changes in essential arterial hypertension?
Case-Control (n=148)
No
Does NOS3 (rs2070744) and GNB3 (rs5443) gene polymorphism correlate with endothelial function impairment and carotid IMT changes in essential arterial hypertension?
Absolute Event Rate: 13.29% vs 22.48%
p-value: p=<0.001
The NOS3 (rs2070744) gene polymorphism, but not GNB3 (rs5443), is associated with essential arterial hypertension severity, endothelial function impairment, and reduced NOS3 gene transcription activity.
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May flag higher-risk hypertension patients for closer monitoring; hypothesis-generating for NOS3 genotyping in endothelial assessment.
Sydorchuk et al. (2022) conducted a case-control in Essential arterial hypertension (n=148). NOS3 (rs2070744) C-allele vs. NOS3 (rs2070744) TT-genotype was evaluated on Total NO metabolites (µmol/l) (p=<0.001). The NOS3 (rs2070744) C-allele was significantly associated with essential arterial hypertension severity, characterized by a 40.88% decrease in NO metabolites and reduced NOS3 transcription activity compared to the TT-genotype.
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